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Part 1: Document Description
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Citation |
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Title: |
High-throughput system to study decision-making across multiple levels of reward and cost |
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Identification Number: |
doi:10.7910/DVN/QADUKS |
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Distributor: |
Harvard Dataverse |
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Date of Distribution: |
2023-06-02 |
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Version: |
5 |
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Bibliographic Citation: |
Ibanez-Alcala, Rodrigo J; Beck, Dirk W.; Salcido, Alexis A.; Villarreal Rodriguez, Kryssia; Davila, Luis D; Drammis, Sabrina M.; Giri, Atanu; Heaton, Cory N.; Rakocevic, Lara I.; Hossain, Safa B.; Reyes, Neftali F.; Zhang, Marie; Batson, Serina A.; Macias, Andrea Y.; Umashankar Beck, Shreeya; Negishi, Kenichiro; Joshi, Arnav; Franco, Austin J; Chavez, Sarah A; Hernández, Bianca; Ramirez, Felix; Ordonez, Miguel; Lopez, Jonathan; Armenta, Abril; Quintanar, Odalys; Medina, Fernanda; Ordonez, Pablo; Martinez, Gustavo; Szafer Braun, Dana; O'Dell, Laura E.; Moschak, Travis M.; Goosens, Ki A; Friedman, Alexander, 2023, "High-throughput system to study decision-making across multiple levels of reward and cost", https://doi.org/10.7910/DVN/QADUKS, Harvard Dataverse, V5 |
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Citation |
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Title: |
High-throughput system to study decision-making across multiple levels of reward and cost |
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Identification Number: |
doi:10.7910/DVN/QADUKS |
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Authoring Entity: |
Ibanez-Alcala, Rodrigo J (University of Texas at El Paso) |
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Beck, Dirk W. (University of Texas at El Paso) |
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Salcido, Alexis A. (University of Texas at El Paso) |
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Villarreal Rodriguez, Kryssia (University of Texas at El Paso) |
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Davila, Luis D (University of Texas at El Paso) |
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Drammis, Sabrina M. (University of Texas at El Paso) |
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Giri, Atanu (University of Texas at El Paso) |
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Heaton, Cory N. (University of Texas at El Paso) |
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Rakocevic, Lara I. (University of Texas at El Paso) |
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Hossain, Safa B. (University of Texas at El Paso) |
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Reyes, Neftali F. (University of Texas at El Paso) |
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Zhang, Marie (University of Texas at El Paso) |
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Batson, Serina A. (University of Texas at El Paso) |
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Macias, Andrea Y. (University of Texas at El Paso) |
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Umashankar Beck, Shreeya (University of Texas at El Paso) |
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Negishi, Kenichiro (University of Texas at El Paso) |
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Joshi, Arnav (University of Texas at El Paso) |
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Franco, Austin J (University of Texas at El Paso) |
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Chavez, Sarah A (University of Texas at El Paso) |
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Hernández, Bianca (University of Texas at El Paso) |
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Ramirez, Felix (University of Texas at El Paso) |
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Ordonez, Miguel (University of Texas at El Paso) |
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Lopez, Jonathan (University of Texas at El Paso) |
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Armenta, Abril (University of Texas at El Paso) |
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Quintanar, Odalys (University of Texas at El Paso) |
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Medina, Fernanda (University of Texas at El Paso) |
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Ordonez, Pablo (University of Texas at El Paso) |
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Martinez, Gustavo (University of Texas at El Paso) |
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Szafer Braun, Dana (University of Texas at El Paso) |
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O'Dell, Laura E. (University of Texas at El Paso) |
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Moschak, Travis M. (University of Texas at El Paso) |
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Goosens, Ki A (University of Texas at El Paso) |
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Friedman, Alexander (University of Texas at El Paso) |
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Distributor: |
Harvard Dataverse |
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Access Authority: |
Davila,Luis |
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Depositor: |
Davila, Luis |
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Date of Deposit: |
2023-04-11 |
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Holdings Information: |
https://doi.org/10.7910/DVN/QADUKS |
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Study Scope |
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Keywords: |
Medicine, Health and Life Sciences, Decision Making, Approach Avoid, Cost Benefit, Rat, high throughput, natural behavior |
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Abstract: |
We designed a system to study decision-making in rats: the Reward-Cost in Rodent Decision-making (RECORD) system. RECORD allows for the creation of a decision-making task battery which leverages natural behaviors in rodents such as searching for food or avoiding threats without the need for food-deprivation. RECORD has three components: 3D-printed configurable arenas, custom electronic hardware, and software for databasing, analysis, and computational modeling. RECORD is fully automated and high throughput, which facilitates the longitudinal study of large cohorts of animals, as well as being cost-effective and quick to build. We validate the ability of RECORD to assess decision-making through experiments comparing individual and sex differences in various cost-benefit conflict tasks. We demonstrate how alcohol, oxycodone, and gut hormone ghrelin manipulations alter decision-making. Using modeling we interpret differences in individual psychometric functions. RECORD measures decision-making functions in rodents similar to those observed in humans, integral to translational studies on psychiatric disorders. |
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Methodology and Processing |
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Sources Statement |
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Data Access |
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Other Study Description Materials |
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2021.zip |
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application/zip |
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OG 2022 Alcohol.zip |
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application/zip |
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OG 2022 Ghrelin.zip |
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application/zip |
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Data Base Backup As 04-11-2023.zip |
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application/zip |
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Database Backup as of 01-26-2024.zip |
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application/zip |
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Excel 1 (For Paper).xlsx |
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Location of Data for v66 (1).docx |
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January (Al Inj).zip |
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