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Part 1: Document Description
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Citation |
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Title: |
Spinal orexin A attenuates opioid-induced mechanical hypersensitivity in the rat |
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Identification Number: |
doi:10.7910/DVN/CYOOXJ |
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Distributor: |
Harvard Dataverse |
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Date of Distribution: |
2022-09-20 |
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Version: |
1 |
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Bibliographic Citation: |
Dong-ho Youn; Jiyeon Jun; Tae Wan Kim; Kibeom Park, 2022, "Spinal orexin A attenuates opioid-induced mechanical hypersensitivity in the rat", https://doi.org/10.7910/DVN/CYOOXJ, Harvard Dataverse, V1 |
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Citation |
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Title: |
Spinal orexin A attenuates opioid-induced mechanical hypersensitivity in the rat |
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Identification Number: |
doi:10.7910/DVN/CYOOXJ |
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Authoring Entity: |
Dong-ho Youn (Department of Oral Physiology, School of Dentistry, Kyungpook National University, Daegu, Korea) |
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Jiyeon Jun (Department of Oral Physiology, School of Dentistry, Kyungpook National University, Daegu, Korea) |
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Tae Wan Kim (Department of Physiology, College of Veterinary Medicine, Kyungpook National University, Daegu, Korea) |
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Kibeom Park (Department of Anesthesiology and Pain Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea) |
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Distributor: |
Harvard Dataverse |
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Access Authority: |
Kibeom Park |
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Depositor: |
Nahm, Francis |
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Date of Deposit: |
2022-09-20 |
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Holdings Information: |
https://doi.org/10.7910/DVN/CYOOXJ |
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Study Scope |
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Keywords: |
Medicine, Health and Life Sciences, Medicine, Health and Life Sciences, Analgesics, Opioid, Dynorphins, Enkephalin, Ala(2)-MePhe(4)-Gly(5)-, Hyperalgesia, Orexins, Orexin Receptors, Pain, Spinal Cord Dorsal Horn |
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Abstract: |
Repeated administration of opioid analgesics for pain treatment can produce paradoxical hyperalgesia via peripheral and/or central mechanisms. Thus, this study investigated whether spinally (centrally) administered orexin A attenuates opioid-induced hyperalgesia (OIH). [D-Ala2, N-Me-Phe4, Gly5-ol]-enkephalin (DAMGO), a selective μ-opioid receptor agonist, was used to induce mechanical hypersensitivity and was administered intradermally (4 times, 1-hour intervals) on the rat hind paw dorsum. To determine whether post- or pretreatments with spinal orexin A, dynorphin A, and antidynorphin A were effective in OIH, the drugs were injected through an intrathecal catheter whose tip was positioned dorsally at the L3 segment of the spinal cord (5 μg for all). Mechanical hypersensitivity was assessed using von Frey monofilaments. |
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Notes: |
KJP-22-174 |
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Methodology and Processing |
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Sources Statement |
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Data Access |
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Other Study Description Materials |
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Label: |
Figure 1_DAMGO Injection on dorsum.xlsx |
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Notes: |
application/vnd.openxmlformats-officedocument.spreadsheetml.sheet |
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Label: |
Figure 2_IT Orexin_Saline_Orexin AS_DMSO_SB674042.xlsx |
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Notes: |
application/vnd.openxmlformats-officedocument.spreadsheetml.sheet |
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Label: |
Figure 3_IT Dyo,Dyn As.xlsx |
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Notes: |
application/vnd.openxmlformats-officedocument.spreadsheetml.sheet |
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Label: |
Figure 4_Pre IT inj(Dyn, Dyn AS, Orexin, Orexin,As).xlsx |
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Notes: |
application/vnd.openxmlformats-officedocument.spreadsheetml.sheet |