A systematic review and meta-analysis of sleep quality in inactive inflammatory bowel diseasedoi:10.7910/DVN/ZNF52CHarvard Dataverse2022-04-101Barnes, Alex, 2022, "A systematic review and meta-analysis of sleep quality in inactive inflammatory bowel disease", https://doi.org/10.7910/DVN/ZNF52C, Harvard Dataverse, V1, UNF:6:beoULkB5R3wxVszaYrKVpA== [fileUNF]A systematic review and meta-analysis of sleep quality in inactive inflammatory bowel diseasedoi:10.7910/DVN/ZNF52CBarnes, AlexHarvard DataverseBarnes, AlexBarnes, Alex2022-03-20Medicine, Health and Life Sciencesinflammatory bowel diseasesleepinflammationBackground Poor sleep in people with inflammatory bowel disease (IBD) has been demonstrated to be prevalent and has been associated with disease activity. This meta-analysis aimed to assess the relationship between poor sleep in inactive inflammatory bowel disease and controls by considering cohort and cross-sectional studies. Methods Electronic databases were searched for publications from inception to November 1st 2021. Poor sleep was defined according to subjective sleep measures. IBD activity was defined according to subjective measures. A random effects model was used to determine the standardised mean difference between poor sleep in inactive IBD and controls. Publication bias was assessed by funnel plot and Egger’s test. Results 519 studies were screened with 9 studies included in the meta-analysis incorporating a total of 729 people with IBD and 508 controls. A random effects model showed a standardised mean difference with poor sleep more frequent in those with inactive IBD than controls with moderate effect size (Hedge’s g 0.41, CI (0.22-0.59) and no significant heterogenitity. There was no publication bias evident. Conclusion Poor sleep is more common in people with inactive IBD than in controls. This suggests that IBD activity may not be the sole driver of the observed poor sleep in this population. Further studies should consider the role of subclinical inflammation in sleep quality in people with IBD.<a href="http://creativecommons.org/publicdomain/zero/1.0">CC0 1.0</a>prevmeta.tab3337text/tab-separated-valuesUNF:6:beoULkB5R3wxVszaYrKVpA==Stata data fileStudyUNF:6:fia2hxVXxHhzICx3H243SQ==Year33.02011.0.2017.45454545454552.2925273865718192020.00.02018.0UNF:6:62kmuTKyH72NMmZ2o6wXxw==CountryUNF:6:8vgjKr4ddQ07q+n82t2p+w==USA1.0.0.45454545454545450.00.00.00.505649896847431633.0UNF:6:gr3yis8pyEruqQtvE1MDXw==Poor sleep definitionUNF:6:HN+X1hmK+taAP+BXdv+TpQ==1.00.00.391674725900320040.18181818181818180.033.00.0.UNF:6:SwTqY0Ndw4gGpVrdF9HbHQ==PopulationUNF:6:n5LKpMhG8aY7kAgLSfDrzw==Sample size34.0102.010634.0.0.0716.45454545454522142.21013340937733.0UNF:6:XKDnn0uw2tDVuGOqs9/8Jw==CD6689.0.457.0937532.01.050.01370.67991979904720.0UNF:6:MScrU1ey8Qo/Ab+7F/aHQA==Controls7.057.031.045.736304221149354.69.8571428571428626.0168.0UNF:6:TklU+td5MXuY4/4YIKW3JQ==Crohn's disease (%)2.00.58003936275359120.00.5636363625526428.1.00.2336003653103105331.0UNF:6:n/dLhDbOC2fJKwd0OoQlzQ==Proportion with poor sleep0.82142859697341920.00.549359941121303733.00.5490196347236633.0.123214912368859730.3199999928474426UNF:6:cG8yJB2RJOBXa597x7O7Gg==Number poor sleep12.0.33.01238.47218775735340.0408.787878787878756.06231.0UNF:6:4fJ/ZBh2sVBRgXuOLR6PGA==Active disease15.00.620000004768371618.0.0.15722678525821660.424999997019767760.385555556250943070.0UNF:6:17MfefxMQZ8HI8blThC3xw==Female31.010.17798594268347.42.053.054.5161290322580642.072.0UNF:6:XWukuZO8dXrSMtn9YvNS1g==Age4.33001061609366842.032.0.40.6562547.025.01.0UNF:6:l1oFVvOHcNloLeHYtSVfyg==Depression0.196852769987188230.0740000009536743213.00.55000001192092920.00.25531914830207825.0.31940147051444423UNF:6:4wjzQWL+HWim0fSQhpMRyQ==TypeUNF:6:BDTfRomkcfWM0/yRhrUpCg==Pubyear0.47946330148538413.30.00.66666666666666670.03.01.01.0UNF:6:0mpc/RfMw7SG85OlPkQ0wg==.0.033.00.72691752689633982.00.01.18181818181818191.0UNF:6:WkvHOzUvOdjcNf+LIdup5w==Poor_sleep_number82.099998474121132.054.9424239649917112.3218814817852354.900001525878906.0.033.0UNF:6:E1CE05IV69urYB4p3XdW5g==Dep_stratified.1.00.00.53452248382484888.025.00.50.5UNF:6:t0zgYsvPaPJQf7U9ZO/xBA==.NaN0.0NaNNaNNaN33.0NaNUNF:6:SymAWOHV/T8vog6tIXc5Eg==Disease duration3.637585184637661218.015.09.0555555555555557.79999995231628415.03.0.UNF:6:Hlz1+Mxpk+BSlFv8tFvRCA==ES0.54901963472366330.32352942228317260.8214285969734192.0.54895796197833440.033.00.12225730104692727UNF:6:KvU9DvIwpoxF6P8YyjpTpA==se(ES)0.081956535577774050.00477648293599486350.04670993611216545.0.033.00.019089697935071690.04791081826569456UNF:6:guqP8MJALC9ezRseiiQrSQ==Lower CI (ES)0.4524271488189697.0.214879214763641360.701588213443756133.00.126085530347231330.00.45536258816719055UNF:6:EugJGYFFndWB67FXIL5XaQ==Upper CI (ES)0.617807269096374533.00.90000146627426150.116734884015090120.44155502319335940.00.638741700035153.UNF:6:/K2PCZJX6VBO89MzvMyinw==Random weight1.6125230789184573.022729158401489333.0.5.1789145469665530.03.03030302669062750.9482679749774872UNF:6:fYDodJKlQ1VBYvPfm/yNzA==Study ID1.017.0.17.033.09.66953980290685833.00.0UNF:6:FgZxzp6EyKKy9BMH5hceMw==Study labelUNF:6:fia2hxVXxHhzICx3H243SQ==Generic ES0.549019634723663333.00.00.32352942228317260.82142859697341920.12225730104692727.0.5489579619783344UNF:6:KvU9DvIwpoxF6P8YyjpTpA==Std. Err. for ES33.00.00477648293599486350.019089697935071690.046709936112165450.08195653557777405.0.047910818265694560.0UNF:6:guqP8MJALC9ezRseiiQrSQ==95% lower CI limit for ES0.0.0.192309327205864470.4524544063321118733.00.72111842615708420.132562900098669640.4550544837077293UNF:6:XP+p6o1JS+kD0SrJs/F3nw==95% upper CI limit for ES0.92173876778975420.6206727819792910.122965667197575260.00.642861440248939433.00.4347217902779392.UNF:6:3HMdRF+LEupfNOKYR7662A==RE(reml) weights for ES7.77369413567856583.36238273074396.70.6473046516898133.00.069.2567103387947253.50489920637773UNF:6:gM7iaTKok/OBmpy5cI8r0w==Regression weights.7.71201518509891572.7596112943054659.8430037011997272.8942337571927815.018.085.43052050678777UNF:6:LRDlizC8F4R71rEvjt+Y1w==