{"id":3781481,"identifier":"DVN/TQIAN4","persistentUrl":"https://doi.org/10.7910/DVN/TQIAN4","protocol":"doi","authority":"10.7910","separator":"/","publisher":"Harvard Dataverse","publicationDate":"2020-03-24","storageIdentifier":"file://10.7910/DVN/TQIAN4","datasetType":"dataset","datasetVersion":{"id":436297,"datasetId":3781481,"datasetPersistentId":"doi:10.7910/DVN/TQIAN4","storageIdentifier":"file://10.7910/DVN/TQIAN4","versionNumber":1,"versionMinorNumber":2,"versionState":"RELEASED","latestVersionPublishingState":"RELEASED","deaccessionLink":"","distributionDate":"2019-11-29","productionDate":"2018-12-26","UNF":"UNF:6:aE7cUTeGhQZuOiE1Isph1A==","lastUpdateTime":"2025-02-05T21:32:48Z","releaseTime":"2025-02-05T21:32:48Z","createTime":"2025-02-05T21:31:50Z","publicationDate":"2020-03-24","citationDate":"2020-03-24","license":{"name":"CC BY 4.0","uri":"http://creativecommons.org/licenses/by/4.0","iconUri":"https://licensebuttons.net/l/by/4.0/88x31.png"},"fileAccessRequest":false,"metadataBlocks":{"citation":{"displayName":"Citation Metadata","name":"citation","fields":[{"typeName":"title","multiple":false,"typeClass":"primitive","value":"Replication Data for: Efficacy and safety of boric acid as a preventive treatment against Saprolegnia infection in Nile tilapia (Oreochromis niloticus)"},{"typeName":"author","multiple":true,"typeClass":"compound","value":[{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Ali, Shimaa"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"WorldFish"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Gamil, Amr A. A."},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"Norwegian University of Life Sciences"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Skaar, Ida"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"Norwegian Veterinary Institute"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Evensen, Øystein"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"Norwegian University of Life Sciences"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Charo-Karisa, Harrison"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"WorldFish"},"authorIdentifierScheme":{"typeName":"authorIdentifierScheme","multiple":false,"typeClass":"controlledVocabulary","value":"ORCID"},"authorIdentifier":{"typeName":"authorIdentifier","multiple":false,"typeClass":"primitive","value":"0000-0001-5323-794X"}}]},{"typeName":"datasetContact","multiple":true,"typeClass":"compound","value":[{"datasetContactName":{"typeName":"datasetContactName","multiple":false,"typeClass":"primitive","value":"Ali, Shimaa"},"datasetContactAffiliation":{"typeName":"datasetContactAffiliation","multiple":false,"typeClass":"primitive","value":"WorldFish"},"datasetContactEmail":{"typeName":"datasetContactEmail","multiple":false,"typeClass":"primitive","value":"Shimaa.Ali@cgiar.org"}}]},{"typeName":"dsDescription","multiple":true,"typeClass":"compound","value":[{"dsDescriptionValue":{"typeName":"dsDescriptionValue","multiple":false,"typeClass":"primitive","value":"Saprolegniosis is a worldwide fungal-like infection affecting freshwater fishes and their eggs. Reports show high mortalities and subsequent economic losses annually from Saprolegnia infections. Most therapeutants against Saprolegnia spp. infections are inefficient and some have negative impact on the environment. In this study, we have investigated the ability of boric acid (BA) to prevent Saprolegniainfection in Nile tilapia (Oreochromis niloticus). BA inhibited radial growth of Saprolegnia hyphae in vitro. Complete in vitro growth inhibition was found at a concentration of ≥0.6 g/L. Inhibitory effects were also observed in vivo when Nile tilapia were experimentally challenged with Saprolegniaspores and followed over 10 days post challenge and under continuous exposure to different BA concentrations. No signs of saprolegniosis were observed in fish treated with BA at concentrations of 0.4 g/L and above. Comet assay revealed that BA has low toxicity in tilapia continuously exposed to concentrations of 0.2–0.6 g/L for 96 h. Additionally, no significant histomorphological changes were observed in BA-treated fish compared to non-treated controls. Alanine Aminotransferase (ALT) and Aspartate Aminotransferase (AST) enzyme levels indicated reduction in systemic tissue damage associated with Saprolegnia infection. This study demonstrates the potential of BA as a prophylactic measure against Saprolegnia infection in tilapia, and we recommend additional studies on environmental impact."}}]},{"typeName":"subject","multiple":true,"typeClass":"controlledVocabulary","value":["Medicine, Health and Life Sciences"]},{"typeName":"keyword","multiple":true,"typeClass":"compound","value":[{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"Boric acid"},"keywordVocabulary":{"typeName":"keywordVocabulary","multiple":false,"typeClass":"primitive","value":"AGROVOC"},"keywordVocabularyURI":{"typeName":"keywordVocabularyURI","multiple":false,"typeClass":"primitive","value":"http://aims.fao.org/aos/agrovoc/c_1016"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"Nile Tilapia"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"Saprolegnia"},"keywordVocabulary":{"typeName":"keywordVocabulary","multiple":false,"typeClass":"primitive","value":"AGROVOC"},"keywordVocabularyURI":{"typeName":"keywordVocabularyURI","multiple":false,"typeClass":"primitive","value":"http://aims.fao.org/aos/agrovoc/c_6797"}}]},{"typeName":"publication","multiple":true,"typeClass":"compound","value":[{"publicationCitation":{"typeName":"publicationCitation","multiple":false,"typeClass":"primitive","value":"Ali, S.E. et al. (2019). Efficacy and safety of boric acid as a preventive treatment against Saprolegnia infection in Nile tilapia (Oreochromis niloticus). Scientific Reports, 9(1): 18013"},"publicationIDType":{"typeName":"publicationIDType","multiple":false,"typeClass":"controlledVocabulary","value":"handle"},"publicationIDNumber":{"typeName":"publicationIDNumber","multiple":false,"typeClass":"primitive","value":"20.500.12348/3828"},"publicationURL":{"typeName":"publicationURL","multiple":false,"typeClass":"primitive","value":"https://hdl.handle.net/20.500.12348/3828"}}]},{"typeName":"language","multiple":true,"typeClass":"controlledVocabulary","value":["English"]},{"typeName":"producer","multiple":true,"typeClass":"compound","value":[{"producerName":{"typeName":"producerName","multiple":false,"typeClass":"primitive","value":"WorldFish"},"producerAffiliation":{"typeName":"producerAffiliation","multiple":false,"typeClass":"primitive","value":"WorldFish"},"producerURL":{"typeName":"producerURL","multiple":false,"typeClass":"primitive","value":"https://www.worldfishcenter.org/"},"producerLogoURL":{"typeName":"producerLogoURL","multiple":false,"typeClass":"primitive","value":"https://www.worldfishcenter.org/sites/default/files/worldfish-logo.jpg"}}]},{"typeName":"productionDate","multiple":false,"typeClass":"primitive","value":"2018-12-26"},{"typeName":"contributor","multiple":true,"typeClass":"compound","value":[{"contributorType":{"typeName":"contributorType","multiple":false,"typeClass":"controlledVocabulary","value":"Funder"},"contributorName":{"typeName":"contributorName","multiple":false,"typeClass":"primitive","value":"FISH CRP"}}]},{"typeName":"distributor","multiple":true,"typeClass":"compound","value":[{"distributorName":{"typeName":"distributorName","multiple":false,"typeClass":"primitive","value":"WorldFish"},"distributorAffiliation":{"typeName":"distributorAffiliation","multiple":false,"typeClass":"primitive","value":"WorldFish"},"distributorURL":{"typeName":"distributorURL","multiple":false,"typeClass":"primitive","value":"https://www.worldfishcenter.org/"},"distributorLogoURL":{"typeName":"distributorLogoURL","multiple":false,"typeClass":"primitive","value":"https://www.worldfishcenter.org/sites/default/files/worldfish-logo.jpg"}}]},{"typeName":"distributionDate","multiple":false,"typeClass":"primitive","value":"2019-11-29"},{"typeName":"depositor","multiple":false,"typeClass":"primitive","value":"WorldFish RDM Team"},{"typeName":"dateOfDeposit","multiple":false,"typeClass":"primitive","value":"2020-03-24"},{"typeName":"timePeriodCovered","multiple":true,"typeClass":"compound","value":[{"timePeriodCoveredStart":{"typeName":"timePeriodCoveredStart","multiple":false,"typeClass":"primitive","value":"2018"}}]},{"typeName":"dateOfCollection","multiple":true,"typeClass":"compound","value":[{"dateOfCollectionStart":{"typeName":"dateOfCollectionStart","multiple":false,"typeClass":"primitive","value":"2018"},"dateOfCollectionEnd":{"typeName":"dateOfCollectionEnd","multiple":false,"typeClass":"primitive","value":"2018"}}]},{"typeName":"kindOfData","multiple":true,"typeClass":"primitive","value":["experimental data"]},{"typeName":"software","multiple":true,"typeClass":"compound","value":[{"softwareName":{"typeName":"softwareName","multiple":false,"typeClass":"primitive","value":"GraphPad prism 8"}}]}]},"geospatial":{"displayName":"Geospatial Metadata","name":"geospatial","fields":[{"typeName":"geographicCoverage","multiple":true,"typeClass":"compound","value":[{"country":{"typeName":"country","multiple":false,"typeClass":"controlledVocabulary","value":"Egypt"}}]}]}},"files":[{"label":"New Microsoft Excel Worksheet.tab","restricted":false,"version":1,"datasetVersionId":436297,"categories":["6. 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A.; Skaar, Ida; Evensen, Øystein; Charo-Karisa, Harrison, 2020, \"Replication Data for: Efficacy and safety of boric acid as a preventive treatment against Saprolegnia infection in Nile tilapia (Oreochromis niloticus)\", https://doi.org/10.7910/DVN/TQIAN4, Harvard Dataverse, V1, UNF:6:aE7cUTeGhQZuOiE1Isph1A== [fileUNF]"}}