{"id":6544173,"identifier":"DVN/CYOOXJ","persistentUrl":"https://doi.org/10.7910/DVN/CYOOXJ","protocol":"doi","authority":"10.7910","separator":"/","publisher":"Harvard Dataverse","publicationDate":"2022-09-20","storageIdentifier":"file://10.7910/DVN/CYOOXJ","datasetType":"dataset","datasetVersion":{"id":333492,"datasetId":6544173,"datasetPersistentId":"doi:10.7910/DVN/CYOOXJ","storageIdentifier":"file://10.7910/DVN/CYOOXJ","versionNumber":1,"versionMinorNumber":0,"versionState":"RELEASED","latestVersionPublishingState":"RELEASED","deaccessionLink":"","lastUpdateTime":"2022-09-20T23:32:49Z","releaseTime":"2022-09-20T23:32:49Z","createTime":"2022-09-20T23:26:57Z","publicationDate":"2022-09-20","citationDate":"2022-09-20","license":{"name":"CC0 1.0","uri":"http://creativecommons.org/publicdomain/zero/1.0","iconUri":"https://licensebuttons.net/p/zero/1.0/88x31.png","rightsIdentifier":"CC0-1.0","rightsIdentifierScheme":"SPDX","schemeUri":"https://spdx.org/licenses/","languageCode":"en"},"fileAccessRequest":true,"metadataBlocks":{"citation":{"displayName":"Citation Metadata","name":"citation","fields":[{"typeName":"title","multiple":false,"typeClass":"primitive","value":"Spinal orexin A attenuates opioid-induced mechanical hypersensitivity in the rat"},{"typeName":"author","multiple":true,"typeClass":"compound","value":[{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Dong-ho Youn"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"Department of Oral Physiology, School of Dentistry, Kyungpook National University, Daegu, Korea"},"authorIdentifierScheme":{"typeName":"authorIdentifierScheme","multiple":false,"typeClass":"controlledVocabulary","value":"ORCID"},"authorIdentifier":{"typeName":"authorIdentifier","multiple":false,"typeClass":"primitive","value":"https://orcid.org/0000-0003-2460-4610"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Jiyeon Jun"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"Department of Oral Physiology, School of Dentistry, Kyungpook National University, Daegu, Korea"},"authorIdentifierScheme":{"typeName":"authorIdentifierScheme","multiple":false,"typeClass":"controlledVocabulary","value":"ORCID"},"authorIdentifier":{"typeName":"authorIdentifier","multiple":false,"typeClass":"primitive","value":"https://orcid.org/0000-0002-4238-2751"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Tae Wan Kim"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"Department of Physiology, College of Veterinary Medicine, Kyungpook National University, Daegu, Korea"},"authorIdentifierScheme":{"typeName":"authorIdentifierScheme","multiple":false,"typeClass":"controlledVocabulary","value":"ORCID"},"authorIdentifier":{"typeName":"authorIdentifier","multiple":false,"typeClass":"primitive","value":"https://orcid.org/0000-0002-7943-4682"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Kibeom Park"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"Department of Anesthesiology and Pain Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea"},"authorIdentifierScheme":{"typeName":"authorIdentifierScheme","multiple":false,"typeClass":"controlledVocabulary","value":"ORCID"},"authorIdentifier":{"typeName":"authorIdentifier","multiple":false,"typeClass":"primitive","value":"https://orcid.org/0000-0002-1432-8301"}}]},{"typeName":"datasetContact","multiple":true,"typeClass":"compound","value":[{"datasetContactName":{"typeName":"datasetContactName","multiple":false,"typeClass":"primitive","value":"Kibeom Park"},"datasetContactAffiliation":{"typeName":"datasetContactAffiliation","multiple":false,"typeClass":"primitive","value":"Department of Anesthesiology and Pain Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea"},"datasetContactEmail":{"typeName":"datasetContactEmail","multiple":false,"typeClass":"primitive","value":"parkkibum@dsmc.or.kr"}}]},{"typeName":"dsDescription","multiple":true,"typeClass":"compound","value":[{"dsDescriptionValue":{"typeName":"dsDescriptionValue","multiple":false,"typeClass":"primitive","value":"Repeated administration of opioid analgesics for pain treatment can\nproduce paradoxical hyperalgesia via peripheral and/or central mechanisms. Thus,\nthis study investigated whether spinally (centrally) administered orexin A attenuates\nopioid-induced hyperalgesia (OIH).\n[D-Ala2, N-Me-Phe4, Gly5-ol]-enkephalin (DAMGO), a selective μ-opioid\nreceptor agonist, was used to induce mechanical hypersensitivity and was administered\nintradermally (4 times, 1-hour intervals) on the rat hind paw dorsum. To determine\nwhether post- or pretreatments with spinal orexin A, dynorphin A, and antidynorphin\nA were effective in OIH, the drugs were injected through an intrathecal\ncatheter whose tip was positioned dorsally at the L3 segment of the spinal cord (5\nμg for all). Mechanical hypersensitivity was assessed using von Frey monofilaments."}}]},{"typeName":"subject","multiple":true,"typeClass":"controlledVocabulary","value":["Medicine, Health and Life Sciences"]},{"typeName":"keyword","multiple":true,"typeClass":"compound","value":[{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"Analgesics, Opioid"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"Dynorphins"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"Enkephalin, Ala(2)-MePhe(4)-Gly(5)-"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"Hyperalgesia"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"Orexins"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"Orexin Receptors"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"Pain"}},{"keywordValue":{"typeName":"keywordValue","multiple":false,"typeClass":"primitive","value":"Spinal Cord Dorsal Horn"}}]},{"typeName":"notesText","multiple":false,"typeClass":"primitive","value":"KJP-22-174"},{"typeName":"depositor","multiple":false,"typeClass":"primitive","value":"Nahm, Francis"},{"typeName":"dateOfDeposit","multiple":false,"typeClass":"primitive","value":"2022-09-20"}]}},"files":[{"label":"Figure 1_DAMGO Injection on dorsum.xlsx","restricted":false,"version":1,"datasetVersionId":333492,"dataFile":{"id":6544175,"persistentId":"","filename":"Figure 1_DAMGO Injection on dorsum.xlsx","contentType":"application/vnd.openxmlformats-officedocument.spreadsheetml.sheet","friendlyType":"MS Excel Spreadsheet","filesize":13844,"storageIdentifier":"s3://dvn-cloud:1835e13b997-2487c4d7c45e","rootDataFileId":-1,"md5":"a7a16e74ed1f77bcb3afd2793acd3688","checksum":{"type":"MD5","value":"a7a16e74ed1f77bcb3afd2793acd3688"},"tabularData":false,"creationDate":"2022-09-20","publicationDate":"2022-09-20","fileAccessRequest":true}},{"label":"Figure 2_IT Orexin_Saline_Orexin AS_DMSO_SB674042.xlsx","restricted":false,"version":1,"datasetVersionId":333492,"dataFile":{"id":6544176,"persistentId":"","filename":"Figure 2_IT Orexin_Saline_Orexin AS_DMSO_SB674042.xlsx","contentType":"application/vnd.openxmlformats-officedocument.spreadsheetml.sheet","friendlyType":"MS Excel Spreadsheet","filesize":571973,"storageIdentifier":"s3://dvn-cloud:1835e13b1b8-3135e8e282f2","rootDataFileId":-1,"md5":"76aebb932826aa592bd3d802c554f1c4","checksum":{"type":"MD5","value":"76aebb932826aa592bd3d802c554f1c4"},"tabularData":false,"creationDate":"2022-09-20","publicationDate":"2022-09-20","fileAccessRequest":true}},{"label":"Figure 3_IT Dyo,Dyn As.xlsx","restricted":false,"version":1,"datasetVersionId":333492,"dataFile":{"id":6544174,"persistentId":"","filename":"Figure 3_IT Dyo,Dyn As.xlsx","contentType":"application/vnd.openxmlformats-officedocument.spreadsheetml.sheet","friendlyType":"MS Excel Spreadsheet","filesize":14382,"storageIdentifier":"s3://dvn-cloud:1835e13b6c9-a3df12123d44","rootDataFileId":-1,"md5":"4dfba9dc0405eb27a2e8c6aca333d7b8","checksum":{"type":"MD5","value":"4dfba9dc0405eb27a2e8c6aca333d7b8"},"tabularData":false,"creationDate":"2022-09-20","publicationDate":"2022-09-20","fileAccessRequest":true}},{"label":"Figure 4_Pre IT inj(Dyn, Dyn AS, Orexin, Orexin,As).xlsx","restricted":false,"version":1,"datasetVersionId":333492,"dataFile":{"id":6544177,"persistentId":"","filename":"Figure 4_Pre IT inj(Dyn, Dyn AS, Orexin, Orexin,As).xlsx","contentType":"application/vnd.openxmlformats-officedocument.spreadsheetml.sheet","friendlyType":"MS Excel Spreadsheet","filesize":20309,"storageIdentifier":"s3://dvn-cloud:1835e13b825-46667c943004","rootDataFileId":-1,"md5":"373867a75abbb1f54517ee4a581c3b0f","checksum":{"type":"MD5","value":"373867a75abbb1f54517ee4a581c3b0f"},"tabularData":false,"creationDate":"2022-09-20","publicationDate":"2022-09-20","fileAccessRequest":true}}],"citation":"Dong-ho Youn; Jiyeon Jun; Tae Wan Kim; Kibeom Park, 2022, \"Spinal orexin A attenuates opioid-induced mechanical hypersensitivity in the rat\", https://doi.org/10.7910/DVN/CYOOXJ, Harvard Dataverse, V1"}}