{"@context":{"@language":"en","@vocab":"https://schema.org/","citeAs":"cr:citeAs","column":"cr:column","conformsTo":"dct:conformsTo","cr":"http://mlcommons.org/croissant/","rai":"http://mlcommons.org/croissant/RAI/","data":{"@id":"cr:data","@type":"@json"},"dataType":{"@id":"cr:dataType","@type":"@vocab"},"dct":"http://purl.org/dc/terms/","examples":{"@id":"cr:examples","@type":"@json"},"extract":"cr:extract","field":"cr:field","fileProperty":"cr:fileProperty","fileObject":"cr:fileObject","fileSet":"cr:fileSet","format":"cr:format","includes":"cr:includes","isLiveDataset":"cr:isLiveDataset","jsonPath":"cr:jsonPath","key":"cr:key","md5":"cr:md5","parentField":"cr:parentField","path":"cr:path","recordSet":"cr:recordSet","references":"cr:references","regex":"cr:regex","repeated":"cr:repeated","replace":"cr:replace","sc":"https://schema.org/","separator":"cr:separator","source":"cr:source","subField":"cr:subField","transform":"cr:transform","wd":"https://www.wikidata.org/wiki/"},"@type":"sc:Dataset","conformsTo":"http://mlcommons.org/croissant/1.0","name":"Replication Data for: Classifying Invasive Lobular Carcinoma as Special Type Breast Cancer May Be Reducing Its Treatment Success: A comparison of Survival Among Invasive Lobular Carcinoma","url":"https://doi.org/10.7910/DVN/AFTWMD","creator":[{"@type":"Person","givenName":"Rusen","familyName":"Cosar","affiliation":{"@type":"Organization","name":"Trakya University Faculty of Medicine"},"name":"Cosar, Rusen"}],"description":"ORIGINAL RESEARCH Cosar et al Classifying Invasive Lobular Carcinoma as Special Type Breast Cancer May Be Reducing Its Treatment Success: A comparison of Survival Among Invasive Lobular Carcinoma Rusen Cosar1, Necdet Sut2 , Sernaz Topaloglu3 , Ebru Tastekin4 , Dilek Nurlu1 , Talar Ozler1 , Eylül Şenödeyici5 , Melisa Dedeli1 , Mert Chousein1, Irfan Cicin3 1Trakya University Faculty of Medicine Department of Radiation Oncology, Edirne, Turkey 2 Trakya University Faculty of Medicine Department of Biostatistics, Edirne, Turkey 3Trakya University Faculty of Medicine Department of Medical Oncology, Edirne, Turkey 4Trakya University Faculty of Medicine Department of Pathology, Edirne, Turkey 5Trakya University Faculty of Medicine, Edirne, Turkey Correspondence: Ruşen Coşar Trakya University School of Medicine, Department of Radiation Oncology, Edirne, Turkey Tel: +902842361074 Email: rusencosar@trakya.edu.tr Disclosure The authors have declared that no competing interests exist. The authors alone are responsible for the content and writing of the paper. The authors declared that this study has received no financial support. “The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.” Voluntary consent form was given to patients or official guardians of deceased patients to use file information. File information was used after the forms were signed by the patient or official guardians of deceased patients. Abstract: Purpose: The literature contains differentiating information regarding the prognosis of invasive lobular carcinoma. We aimed to address the inconsistency by comparatively examining the clinical features and prognosis of invasive lobular carcinoma patients in our university and to report our experience by dividing our patients into various subgroups. Patients and methods: Records of patients with breast cancer admitted to Trakya University School of Medicine Department of Oncology between July 1999 and December 2021 were reviewed. The patients were divided into three groups (No-Special Type Breast Cancer, Invasive Lobular Special Type BC, No-Lobular Special BC). Patient characteristics, treatment methods and oncological results are presented. Survival curves were generated using the Kaplan–Meier method. Statistical significance of survival among the selected variables was compared by using the log-rank test. Results: The patients in our study consisted of 2142 female and 15 male breast cancer patients. There were 1814 patients with Non-Special Type Breast Carcinoma, 193 patients with Lobular Special Type Breast Carcinoma, and 150 patients with Non-Lobular Special Type Breast Carcinoma. The duration of disease free survival (DFS) was 226.5 months for the No-Special Type group, 216.7 months for the No-Lobular Special Type group, and 197.2 months for the Lobular Special Type group, whereas the duration of overall survival (OS) was 233.2 months for the Non-Special Type group, 227.9 for the No-Lobular Special Type group, and 209.8 for the Lobular Special Type group. The duration of both DFS and OS was the lowest in the Lobular Special Type group. Multivariate factors that were significant risk factors for OS were Lobular Special Type histopathology (p=.045), T stage, N stage, stage, skin infiltration, positive surgical margins, high histological grade and mitotic index. Modified radical mastectomy, chemotherapy, radiotherapy and use of Tamoxifen and aromatase inhibitors for more than 5 years were significant protective factors for overall survival. Conclusion: The histopathological subgroup with the worst prognosis in our study was Lobular Special Type. Duration of DFS and OS were significantly shorter in Lobular Special Type than No-Lobular Special Type group. Whether Lobular Special Type should be classified as a Special Type Breast Tumor should be reconsidered, and a more accurate treatment and follow-up process may be required. Keywords: No-Special Type Breast Cancer, Special Type Breast Cancer, Invasive Lobular Cancer, Non-Lobular Special Type Breast Cancer, Invasive Ductal Breast Cancer Introduction Invasive lobular breast cancer (ILC) is the most common special histological type of breast cancer (BC). While ILC accounts for 5% of invasive carcinomas, its incidence has increased up to 10-14% with the developments in diagnostic methods and novel discoveries. However, ILC remains less common in Asian populations (2–6%)1-6. As the incidence of ILC is significantly less than invasive ductal carcinoma (IDC), the most common histopathological subtype of breast cancer, its clinical and prognostic features and biological behavior become clearer as more studies are published7-15. ILC is within the Special Type BC group, along with tubular, mucinous, papillary, micropapillary, medullary, metaplastic, and apocrine histopathological subtypes, whereas IDC is among the No-Special Type BC group composed of highly heterogeneous subtypes10. ILC...","keywords":["Medicine, Health and Life Sciences","invazive lobular breast carcinoma","breast carcinoma","special type berast carcinoma"],"license":"http://creativecommons.org/publicdomain/zero/1.0","datePublished":"2023-02-08","dateModified":"2023-02-08","includedInDataCatalog":{"@type":"DataCatalog","name":"Harvard Dataverse","url":"https://dataverse.harvard.edu"},"publisher":{"@type":"Organization","name":"Harvard Dataverse"},"version":"2.1","citeAs":"@data{DVN/AFTWMD_2023,author = {Cosar, Rusen},publisher = {Harvard Dataverse},title = {Replication Data for: Classifying Invasive Lobular Carcinoma as Special Type Breast Cancer May Be Reducing Its Treatment Success: A comparison of Survival Among Invasive Lobular Carcinoma},year = {2023},url = {https://doi.org/10.7910/DVN/AFTWMD}}","distribution":[{"@type":"cr:FileObject","@id":"Figure 1a..tif","name":"Figure 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