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To determine\nwhether post- or pretreatments with spinal orexin A, dynorphin A, and antidynorphin\nA were effective in OIH, the drugs were injected through an intrathecal\ncatheter whose tip was positioned dorsally at the L3 segment of the spinal cord (5\nμg for all). Mechanical hypersensitivity was assessed using von Frey monofilaments."},"citation:keyword":[{"citation:keywordValue":"Analgesics, Opioid"},{"citation:keywordValue":"Dynorphins"},{"citation:keywordValue":"Enkephalin, Ala(2)-MePhe(4)-Gly(5)-"},{"citation:keywordValue":"Hyperalgesia"},{"citation:keywordValue":"Orexins"},{"citation:keywordValue":"Orexin Receptors"},{"citation:keywordValue":"Pain"},{"citation:keywordValue":"Spinal Cord Dorsal Horn"}],"citation:datasetContact":{"citation:datasetContactName":"Kibeom Park","citation:datasetContactAffiliation":"Department of Anesthesiology and Pain Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea","citation:datasetContactEmail":"parkkibum@dsmc.or.kr"},"author":[{"citation:authorName":"Dong-ho Youn","citation:authorAffiliation":"Department of Oral Physiology, School of Dentistry, Kyungpook National University, Daegu, Korea","authorIdentifierScheme":"ORCID","authorIdentifier":"https://orcid.org/0000-0003-2460-4610"},{"citation:authorName":"Jiyeon Jun","citation:authorAffiliation":"Department of Oral Physiology, School of Dentistry, Kyungpook National University, Daegu, Korea","authorIdentifierScheme":"ORCID","authorIdentifier":"https://orcid.org/0000-0002-4238-2751"},{"citation:authorName":"Tae Wan Kim","citation:authorAffiliation":"Department of Physiology, College of Veterinary Medicine, Kyungpook National University, Daegu, Korea","authorIdentifierScheme":"ORCID","authorIdentifier":"https://orcid.org/0000-0002-7943-4682"},{"citation:authorName":"Kibeom Park","citation:authorAffiliation":"Department of Anesthesiology and Pain Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea","authorIdentifierScheme":"ORCID","authorIdentifier":"https://orcid.org/0000-0002-1432-8301"}],"title":"Spinal orexin A attenuates opioid-induced mechanical hypersensitivity 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