{"status":"OK","data":{"id":55601,"identifier":"DVN/6IXW9Z","persistentUrl":"https://doi.org/10.7910/DVN/6IXW9Z","protocol":"doi","authority":"10.7910","separator":"/","publisher":"Harvard Dataverse","publicationDate":"2010-10-19","storageIdentifier":"s3://1902.1/15205","effectiveDatasetFileCountLimit":1000,"datasetFileUploadsAvailable":999,"datasetType":"dataset","locks":[],"latestVersion":{"id":54342,"datasetId":55601,"datasetPersistentId":"doi:10.7910/DVN/6IXW9Z","datasetType":"dataset","storageIdentifier":"s3://1902.1/15205","versionNumber":1,"internalVersionNumber":1,"versionMinorNumber":0,"versionState":"RELEASED","latestVersionPublishingState":"RELEASED","deaccessionNote":"","deaccessionLink":"","lastUpdateTime":"2010-10-18T15:34:06Z","releaseTime":"2010-10-19T00:00:00Z","createTime":"2010-10-18T15:33:41Z","alternativePersistentId":"hdl:1902.1/15205","publicationDate":"2010-10-19","citationDate":"2010-10-19","effectiveDatasetFileCountLimit":1000,"datasetFileUploadsAvailable":999,"license":{"name":"CC0 1.0","uri":"http://creativecommons.org/publicdomain/zero/1.0","iconUri":"https://licensebuttons.net/p/zero/1.0/88x31.png","rightsIdentifier":"CC0-1.0","rightsIdentifierScheme":"SPDX","schemeUri":"https://spdx.org/licenses/","languageCode":"en"},"fileAccessRequest":false,"metadataBlocks":{"citation":{"displayName":"Citation Metadata","name":"citation","fields":[{"typeName":"title","multiple":false,"typeClass":"primitive","value":"Androgen Receptor Regulates a Distinct Transcription Program in Adrogen-Independent Prostate Cancer"},{"typeName":"author","multiple":true,"typeClass":"compound","value":[{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Qianben Wang"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"Dana-Farber Cancer Institute/Harvard Medical School"}},{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"et al."}}]},{"typeName":"datasetContact","multiple":true,"typeClass":"compound","value":[{"datasetContactEmail":{"typeName":"datasetContactEmail","multiple":false,"typeClass":"primitive","value":"N/A"}}]},{"typeName":"dsDescription","multiple":true,"typeClass":"compound","value":[{"dsDescriptionValue":{"typeName":"dsDescriptionValue","multiple":false,"typeClass":"primitive","value":"INSTRUCTIONS: Please enter one of the following Topic Classifications in the section below:  Bioinformatics\n& Computational Biology Genes & Environment Genetic & Molecular Epidemiology Medical Genomics Molecular Genetics Proteomics Statistical Genetics, Genomics, and Omics"}},{"dsDescriptionValue":{"typeName":"dsDescriptionValue","multiple":false,"typeClass":"primitive","value":"The evolution of prostate cancer from an androgen dependent state to one that is androgen-independent marks its lethal progression. The androgen receptor (AR) is essential in both, though its function in androgen-independent cancers is poorly understood. We have defined the direct AR-dependent target genes in both androgen-dependent and -independent cancer cells by generating AR-dependent gene expression profiles and AR cistromes. In contrast to what is found in androgen-dependent cells, AR selectively upregulates M-phase cell-cycle genes in androgen-independent cells, including UBE2C, a gene that inactivates the M-phase checkpoint. We find that epigenetic marks at the UBE2C enhancer, notably histone H3K4 methylation and FoxA1 transcription factor binding, are present in androgen-independent cells and direct AR-enhancer binding and UBE2C activation. Thus, the role of AR in androgen-independent cancer cells is not to direct the androgen-dependent gene expression program without androgen, but rather to execute a distinct program resulting in androgen-independent growth."}}]},{"typeName":"dateOfDeposit","multiple":false,"typeClass":"primitive","value":"2010-10-18"}]}},"files":[{"description":"","label":"Cell09_245.pdf","restricted":false,"version":1,"datasetVersionId":54342,"dataFile":{"id":1581697,"persistentId":"doi:10.7910/DVN/6IXW9Z/XY22SM","pidURL":"https://doi.org/10.7910/DVN/6IXW9Z/XY22SM","filename":"Cell09_245.pdf","contentType":"application/pdf","friendlyType":"Adobe PDF","filesize":1845394,"description":"","storageIdentifier":"s3://dvn-cloud:61871","rootDataFileId":-1,"md5":"90fa52f86944f9da88c9bae66e8a0304","checksum":{"type":"MD5","value":"90fa52f86944f9da88c9bae66e8a0304"},"tabularData":false,"creationDate":"2010-10-18","publicationDate":"2010-10-18","lastUpdateTime":"2010-10-18T15:34:06Z","fileAccessRequest":false}}]}}}